Sunday 17 November
2nd Workshop on Integrated Exposure and Effects Analysis | 8:00 a.m.–5:00 p.m. | Room: Ryman Studio ABC
For more information, visit www.nies.go.jp/health/ieea/index.html.
Whither the Research? Prioritizing Pharmaceuticals and Personal Care Products for Advanced Environmental Study | 8:00 a.m.–12 p.m. | Room: Lincoln DE
A recent horizon scanning workshop performed by SETAC’s Global Pharmaceuticals Advisory Group identified 20 major research needs to define the risks of pharmaceuticals and personal care products (PPCPs) in the environment. These research needs were then ranked by scientists from academia, industry and government. One of top ranked questions was, “What approaches should be used to prioritize PPCPs for research on environmental and human health exposure and effects?” Though several approaches have been proposed, each possess strengths and limitations that appear critical for specialized application. We now recognize that such approaches require further development for different situations covering different geographical regions, climates, demographics, and cultural backgrounds and should be designed in such a way that they account for the use practices, complex fate processes, and the specific modes of action associated with many PPCPs. This timely workshop will include perspectives and recommendations by a group of experts and is thus aimed to advance this critical research need. It will be of particularly interest to graduate students and professionals studying environmental toxicology, chemistry and risks of PPCPs and other industrial contaminants.
Mechanistic Effect Models for Ecological Risk Assessment: Recent Progress and Future Directions | 1:00 p.m.–5:30 p.m. | Room: Lincoln DE
There are various pressures to develop new approaches to the ecological risk assessment of chemicals. On the one hand there is pressure to test more chemicals, leading to economic pressures to reduce the costs of tests and to speed them up, and also ethical pressures to reduce the use of animals in testing. One response to these pressures is to make better use of observations on suborganismal responses arising from chemical perturbations to make an assessment of the likelihood of impact on targets of concern. Frameworks such as Adverse Outcome Pathway (AOP) take this approach. This framework offers the promise of identifying mechanisms that are responsive to chemical perturbation and of building in vitro testing methods around them. On the other hand, there are also calls for developing more holistic risk assessments that are more in tune with the needs of risk management, that relate more obviously to the objects of protection, and that thus express impacts in terms of health and/or ecosystem services. Finally, there are calls for approaches that make more explicit links between exposure and effects and that move away from expressing risks in terms of simple thresholds and toward outputs that can better inform management decisions. Mechanistic effect models encompass a broad range of quantitative tools to address these issues and support the quantification of risks for tested and untested chemical stressors.
Speakers representing the academia, government and business tripartite are participating in this workshop to discuss how lessons learned from recent and ongoing initiatives in Europe and North America could facilitate the development and implementation of predictive modeling tools in the regulatory risk assessment of chemicals. The workshop is a mix of invited talks and panel discussions where audience participation is encouraged.
Wednesday 20 November
Animal Alternatives Strategies and Testing Approaches | 6:30 p.m.–8:00 p.m. | Cheekwood AB
The SETAC Animal Alternatives Advisory Group (AAAG) will host a special session using the "PechaKucha" format. Four talks will be given, each a total of 400 seconds. Lean back and watch the speakers deal with this challenge because even experienced speakers start sweating when giving a PechaKucha! The purpose of this special session is to share information on developments in alternative approaches and technologies for ecotoxicology research and safety testing and discuss challenges for application of non-animal methods for risk assessment in a regulatory context.
- Alternatives Methods for Fish Testing: HESI Program Initiatives | Michelle R. Embry
- A Path toward Effluent Toxicity Test Alternatives with Fish | Jim T. Oris
- When Is a Fish a Fish? A View on Fish Development in Animal Alternatives Globally | Scott Belanger
- Reduce, Replace, and Refine: Options for Fish Sublethal Testing | Teresa J. Norberg-King